The 48-year-old actor, who starred in the show with actress Jennifer Garner, said he is totally up for reunion, reported E! News.
"I always joke that if they do, they better hurry up, because I'm getting up there in age.
"Running down those hallways, you know, I'm not 30 anymore so... I would definitely be interested, but I haven't heard anything about it," Vartan said.
The "Monster-in-Law" actor also said if the reunion happens, he would want the network to retain the old cast.
The series went off air in 2006 after a run of five years.