In a 15-minute address to the convention, the lawyer- turned-first lady proved to be the 'perfect Trump antidote', doing more than any governor or congressman to unite and fire up the party for November's presidential election in the face of another non-politician, Donald Trump, from the rival Republican camp.
The election of the first African American president, and now potentially the first woman president, were testament to the true America and a repudiation of all Trump stands for, she said, without taking his name.
"The story of generations of people who have felt the lash of bondage, the shame of servitude, the sting of segregation but who kept on striving and doing what needed to be done so that today I wake up every morning in a house that was built by slaves and I watch my daughters, two beautiful, intelligent black young women, playing with their dogs on the White House lawn."
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"How we explain that when someone is cruel or acts like a bully, you don't stoop to their level. No, our motto is: 'When they go low, we go high'," she added.
Among the thousands of audience was former president Bill Clinton, who was caught on camera mouthing the word "wow" as Michelle delivered one of the most passionate speeches of the election year.
Not even Vermont Senator Bernie Sanders could quiet the shouts of his die-hard supporters - but Michelle did in what Obama called in a Twitter post as an "incredible speech by an incredible woman".