Rondi Reed, who plays Mike's mother, Peggy, on the show, wrote on Facebook that the show's sixth season would be its last, reported Entertainment Weekly.
The sixth season was also shortened from 22 episodes to 13.
"The network has its reasons, and I will not get into a debate, discussion, or campaign to get them to change their minds. Other venues were explored by WB and Bonanza Productions (Chuck Lorre) after CBS announced their intentions, but did not turn up a future for our show," Reed wrote.
"It is a fact and we have known for a few weeks. I remain extremely grateful to have been a part of this and to have worked with a fabulous bunch of folks over the years.
"I have learned a lot about many things, including the Business we call Show. Also grateful for all the fans and for the personal support I have received over the (almost) 6 seasons," she wrote.
The show, which stars Melissa McCarthy and Billy Gardell, was renewed for a sixth season back in March.