Kunis, 32, is executive producing under her Orchard Farm Productions alongside the "Halloween" filmmaker, who also will direct, reported Deadline.
Created and written by Joey Slamon ('Arrested Development'), "Trapped" takes places over a single night in the home of a wealthy family under attack by a murderous cult.
Orchard Farm's Susan Curtis, Cami Curtis and Lisa Sterbakov also executive produce.
"We're excited to work in partnership with Rob Zombie as well as Mila Kunis and her Orchard Farm Productions associates Susan Curtis, Cami Curtis and Lisa Sterbakov on this horror comedy series," Starz Managing Director Carmi Zlotnik said.