An additional three million children in Syria and Iraq have been forced out of school by conflict, UNICEF said in a new report.
The joint report by UNICEF and UN cultural agency UNESCO's Institute for Statistics said the rates of out-of-school children in the region had been declining, "often by as much as half."
"But in recent years, progress has stalled," it said, with 4.3 million primary-aged children and 2.9 million lower secondary-aged children out of school.
That figure represents around 15 percent of the children in the Middle East who should be receiving pre-primary, primary or secondary education.
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Yemen had the worst rate of pre-primary school age children receiving an education, with only six percent of them in school.
Djibouti and Sudan had the worst rates for secondary school-age children, followed by Iran and Morocco.
The report said a study of nine countries in the region revealed a range of reasons why children were out of school, including poverty.
"Children from poor, disadvantaged families are most likely to be excluded from schooling, even though they have the most to gain," Maria Calivis, UNICEF's regional director, said at the report's launch in Beirut on Wednesday.
Gender discrimination also remains a factor.
"Girls are undervalued and, since they are not expected to work, their families see no need for them to learn," the report says, adding that early marriage is also an issue in most countries in the region.
Elsewhere, violence is a problem -- either inside schools, or in conflict zones like Syria and Iraq, where millions of children no longer have access to education and schools have been caught up in violence.
"I used to go to school, before the soldiers came," one child said in a video produced by UNICEF.
The report said keeping children in school after enrolment was a key problem, with high drop-out rates at most levels in many countries in the region.