At lunch, Pakistan were 336 for five -- 39 runs ahead of England's 297. Misbah was 44 not out, his so far two-hour innings featuring five fours in 89 balls.
By contrast, Sarfraz Ahmed had made a typically brisk 20 not out off just 27 balls. Pakistan had scored at a modest rate of barely three runs an over during Friday's morning session but they had now kept England in the field for nearly eight-and-a-half hours in total.
All-rounder Chris Woakes, who had dismissed Azhar, struck again on his Warwickshire home ground when he got rid of Younis for 31.
Younis has developed a habit of walking well across his stumps and it meant that when he tried to glance Woakes he was caught down the legside by Jonny Bairstow, rather than the ball evading the wicket-keeper's gloves.
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But two balls later Misbah, showing the value of patience and good judgement, drove Broad down the ground. Broad though found his range when a full-length delivery smashed into Asad Shafiq's off stump for an 18-ball nought to leave Pakistan 296 for five, still one run behind.
Misbah's single to third man off Broad saw Pakistan into the lead. Joe Root, wearing a helmet, came into an extraordinarily close short third slip position in a bid to counter Misbah's tactic of playing defensively at fast bowler Steven Finn with soft hands.
Pakistan's batsmen have found Moeen Ali to their liking this series and Misbah reverse-swept him four when the off-spinner came on shortly before lunch. Wicket-keeper Ahmed followed up with two swept fours in as many balls off Ali.