Pakistan snatched the proverbial "defeat from the jaws of a win" in the first of five one-day internationals in Sharjah on Wednesday.
Chasing a modest 184-run target, Pakistan were in sight of victory at 165-4 in the 41st over, but lost their last six wickets off just 39 balls in the space of 17 runs.
But Misbah said Friday's second game in Dubai was alltogether a different prospect.
"If we keep recalling about what happened in the last match it will be difficult. We must forget that and all our players should play the next match as a new game," said Misbah.
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Misbah said he was disappointed at his batsmen's failures.
"The last six batsmen should have batted, knowing how many runs were needed to score. It is very disappointing that they played very irresponsible shots," he said
"I think it is high time players understand how to play under such situations," added Misbah, whose dismissal for 31 in the 36th over proved to be the turning point.