Maya Vadiveloo from University of Rhode Island and Josiemer Mattei from Harvard University T H Chan School of Public Health in the US, analysed weight discrimination data from the long-term study, Midlife Development in the US.
The researchers focused on respondents who reported regularly experiencing discrimination because of their weight.
The study asked whether they were treated discourteously, called names, or made to feel inferior.
That stress can lead to heart disease, diabetes, inflammation and other disorders, increasing risk of death.
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"Even if we accounted for health effects attributed to being overweight, these people still experience double the risk of allostatic load because of weight discrimination," said Vadiveloo.
The findings expose flaws in society's approach to weight control, she said.
"The main message is to be aware that the way we treat people may have more negative effects than we realise," she said.
"There is so much shaming around food and weight. We need to work together as a nation on improving public health and clinical support for individuals with obesity and targeting environmental risk factors," she added.
The study was published in the journal Annals of Behavioural Medicine.
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