Upham was found dead on October 16, more than a week after she was reported missing by her father. She was 32.
While the reason of her demise has not been determined yet, her family has called the death accidental, said the Huffington Post.
Lewis took to Twitter to share her concerns about the reason of Upham's death. She said it might linked to her speaking out about the Native American community.
The next day, the 'Natural Born Killers' star wrote that she couldn't sleep, as she felt sad about the loss of Upham and about 'how she died'.
Also Read
Lewis added that she didn't want Upham's previous emotional issues, nor tension within the Native American community, to distract from the investigation.
Lewis also tweeted, "Misty told me about horrible violence she suffered on NA reservations. She felt she (could) be murdered! (Because) she was vocal. This is not a suicide."
The tweet has since been deleted.