The movie, starring Hrithik Roshan and debutant Pooja Hegde, will be screened at Piazza Grande on August 13, which is the last day of the festival.
Gowariker's Aamir Khan-starrer "Lagaan" was also screened at Locarno International Film Festival and this is the second time the director will attend the prestigious movie carnival.
"When 'Lagaan' was screened at the same Piazza, on a giant screen, one of the biggest in the world, it was an out-of-the-world experience to see an audience of 8000 plus of different nationalities, applaud the film. I am looking forward to Locarno this time with 'Mohenjo Daro'," Gowariker said in a statement.
The movie has been produced by Siddharth Roy Kapur and Sunita Gowariker and is set to release on August 12.
"We are thrilled that the film will be showcased to the European audience as part of the Closing Day gala," Amrita Pandey, VP-Studios, Disney India, added.