Monaco slumped to their sixth defeat in all competitions this season when they lost 2-0 at Saint Etienne, a worrying setback just days before they face Borussia Dortmund in the Champions League.
Monaco, runners-up in Ligue 1 to Paris Saint Germain last season, remain third from bottom of the table with just one victory -- achieved on the opening day of the campaign -- to their name.
Friday's loss was Monaco's second defeat of the week after they went down 1-0 to Angers on Tuesday.
That embarrassment prompted under-fire coach Leonardo Jardim to make seven changes to his starting line-up but the radical surgery had little effect.
Radamel Falcao wasted a handful of chances before Saint Etienne took a grip on the game.
Tunisian midfielder Wahbi Khazri opened the scoring four minutes before half-time when he latched on to a cross from Norwegian teammate Ole Selnaes to beat Monaco goalkeeper Diego Benaglio.
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Khazri added a second in the 54th minute for his 40th career goal in Ligue 1 and his fourth of the season.
"Defensively, we made mistakes for which we paid dearly, especially on Khazri's first goal," admitted Jardim.
"We need to pay more attention to these type of situations. In principle, if we have six chances then we must score two or three goals but our players lack confidence."
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