It said Fox had paid the five women a total of USD 13 million in exchange for their silence and agreeing not to pursue litigation against the news channel, a favorite among conservatives.
While two of the cases were previously known, the Times said it had unearthed three more cases of harassment, two of a sexual nature and one alleging abusive behavior by O'Reilly.
The five women either worked on his program, "The O'Reilly Factor," or made regular appearances on it.
In a carefully worded statement posted on his website, O'Reilly did not actually deny any of the allegations, but said his prominence made him "vulnerable to lawsuits from individuals who want me to pay them to avoid negative publicity."
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O'Reilly, who is 67, is one of the most prominent faces on American television. "The O'Reilly Factor" is watched by some 450,000 viewers a day, one of Fox's biggest audiences.
Fox News did not immediately reply to requests from AFP for comment.
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