The crash happened when the Macau-bound ferry -- reported to be a jetfoil boat -- was approaching the port at around 9.30 am (0130 GMT) and hit a concrete breakwater, a spokesman for Macau's marine department said.
The authorities earlier said around 20 people were injured but later put the figure at 57.
"The vessel was carrying a total of 220 passengers and 13 crew members. Fifty-seven passengers have suffered minor injuries, including two Koreans and one Japanese," a spokeswoman for Shun Tak, which operates the ferry services, said in a statement.
Local broadcaster RTHK said the ferry involved was a jetfoil and the cause of accident was yet to be determined.
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It is the third accident on the Hong Kong to Macau ferry route in the past eight months.
In November, a high-speed ferry travelling from Hong Kong to Macau hit an "unidentified object" near one of Hong Kong's small outlying islands, injuring 87 people.
And last month a Hong Kong-bound Macau ferry collided with a mainland Chinese vessel, leaving 33 injured.
Fears over maritime safety in Hong Kong were sparked after a fatal collision between a passenger ferry and a pleasure boat carrying around 120 people claimed 39 lives in October 2012.
An inquiry into the crash found a "litany of errors" and "systematic failings" in the marine department's safety standards.
Fatal boat accidents are rare in Hong Kong despite its crowded waters, which often see high-speed hydrofoils vying for space with tourist junks, luxury yachts and a century-old public ferry system.