The trouble started when the four youths had gone for tuition classes in the colony last evening. A group of people allegedly attacked them claiming that they were indulging in eve-teasing, police said.
The boys were rescued by the police and were admitted to hospital.
Irate protesters laid a siege at a police station demanding action against those who had beaten up the boys.
Police have registered a case against 150 people for the violence and named three of them.
Security has been tightened and paramilitary personnel have been deployed in sensitive areas in Muzaffarnagar.
The western Uttar Pradesh district has witnessed a string of communal incidents since the riots in September last year that left over 60 people dead and hundreds of others displaced.