Mavis Wanczyk said she had played the lottery as a "pipe dream," never believing that it would one day be possible for her to retire early from the Mercy Medical Center, where she worked in patient care.
Yesterday that dream came true.
"I've called them and told them I will not be coming back," she said to laughter at a news conference hosted by the Massachusetts State Lottery.
Wanczyk selected the winning numbers - which included family birthdays - and bought the ticket from a convenience store in Chicopee, a small town 100 miles (160 kilometres) west of Boston, calling it "a chance I had to take."
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"I was just there to buy it for luck," she explained, chewing gum and grinning. Accompanied to the news conference by her mother and two sisters, she was still dazed after her monumental win.
A local man, accused of driving a pickup truck at high speed, was subsequently charged with offences including motor vehicle homicide, manslaughter while under the influence and leaving the scene.
Powerball called Wednesday's draw "the highest jackpot won on a single ticket and the biggest lottery prize ever awarded to one single person."
The USD 758.7 million jackpot is Powerball's highest since a January 2016 world record of USD 1.6 billion, which was split between three ticket holders from California, Florida and Tennessee. Each took home USD 528.8 million.
The retailer that sold the winning ticket is to receive USD 50,000, which he has committed to local charities.
Wanczyk now has the choice of taking the jackpot as an annuity spread over 30 years or a one-off cash lump sum - reportedly USD 336 million after taxes.
"The first thing I want to do? I just want to sit back and relax. I had a pipe dream and my pipe dream has finally come true," Wanczyk said.
"I couldn't drive anywhere, I couldn't do anything," she said. "So he followed me actually to make sure I was safely home.