Mothers who smoke damage fertility of their sons

Mothers who smoke while they are pregnant or breast feeding may be damaging the fertility of their sons, a new research has warned.
It is already known that smoking during pregnancy can have a number of harmful effects on the developing foetus, but, until now, the effects on the fertility of male offspring and the mechanisms involved have been unclear.
Researchers used a mouse animal model, which directly mimics human smoking, to look at what effects the mother's smoking during pregnancy and breast feeding has on the fertility of her male pups.
They developed a machine that draws smoke into a nose piece; 27 female mice were placed in the machine with their noses introduced into the nose piece and they inhaled the smoke into their lungs in exactly the same way as a human would when smoking a cigarette.

The amount of smoke inhaled represented the equivalent of a pack of 24 cigarettes a day in humans. Another 27 mice were exposed to normal air. After six weeks all the mice were placed with males to produce litters.
Exposure to cigarette smoke continued in the "smoking" mice throughout pregnancy and lactation until the pups were weaned. The 108 male mice offspring were examined regularly through to adulthood.

"Our results show that male pups of 'smoking' mothers have fewer sperm, which swim poorly, are abnormally shaped and fail to bind to eggs during in vitro fertilisation studies," said Professor Eileen McLaughlin, Co-Director of the Priority Research Center in Chemical Biology at the University of Newcastle in Australia, who led the study.

"Consequently, when these pups reach adulthood they are sub fertile or infertile. This is the first time we have been able to prove conclusively that male baby exposure to cigarette toxins in pregnancy and early life will damage later life fertility," said McLaughlin.
"We now know that exposure to cigarette toxins directly affects the stem cell population in the testes, causing a permanent reduction in the population of sperm produced.
"We also know that oxidative stress induced by these toxins causes damage to the nuclei and mitochondria (the cell's 'power' supply) of cells in the testes and this results in sperm with abnormal heads and tails, that are unable to swim properly or successfully bind and fuse with eggs," said McLaughlin.

"Although this is a study in mice, the findings are relevant to human health as many men, now in their 30s and 40s, were exposed to cigarette toxins in the womb when it was less well known that smoking affected babies' health.
"These men have difficulty conceiving and this is associated with production of low numbers of poor quality sperm in their semen," McLaughlin added.
The research was published in the journal Human Reproduction.