Jose Mourinho's astonishing feud with Paul Pogba will take another twist when Manchester United's warring duo head to West Ham, while Chelsea's Eden Hazard bids to inflict more misery on Liverpool.
On any other weekend, the showdown between Premier League leaders Liverpool and title rivals Chelsea at Stamford Bridge would be the centre of attention.
But United manager Mourinho is embroiled in a clash of egos with France midfielder Pogba that threatens to derail his side's season.
Mourinho and Pogba were filmed in a heated discussion at United's training ground on Wednesday, just 24 hours after the World Cup winner was told he would no longer be the team's vice-captain.
The volatile Pogba reportedly infuriated Mourinho by making it clear he wants to join Barcelona and poured fuel on the fire when he criticised the manager's cautious tactics in last weekend's draw with Wolves.
With United players said to be taking sides on the row, Mourinho is facing a toxic situation that could divide the club.
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There was further woe for Mourinho on Tuesday as United, with the rested Pogba watching from the stands, were dumped out of the League Cup third round in an embarrassing defeat against second tier Derby.
United are already eight points behind Liverpool and can ill-afford another setback in an already traumatic campaign.
Against that tense backdrop, the announcement of United's team-sheet at West Ham on Saturday will be eagerly awaited to see whether Pogba will be recalled or be consigned to exile.
Regardless of Pogba's presence, United must raise their effort levels, according to their veteran defender Ashley Young.
"I think they had more intensity than we did," Young said of the Derby defeat.
"You have to show that intensity and go further than the opposition. We didn't do that and I think we got punished."
"He is establishing himself in the top three players in the world now, and at the minute, he's probably the best player in the world."
"We can do better and now we know more. I think we were well prepared but the game will help massively."
Fixtures (1400 GMT unless stated)
Saturday Arsenal v Watford, Chelsea v Liverpool (1630 GMT), Huddersfield v Tottenham, Everton v Fulham, Manchester City v Brighton, Newcastle v Leicester, West Ham v Manchester United (1130 GMT), Wolves v Southampton
Sunday Cardiff v Burnley (1500 GMT)