Sattar was returning from Hyderabad to Karachi with his two police guards when his driver lost control and went off the road near Nooriabad area on the highway on Saturday night.
Motorway SSP Karamullah Soomro said the two guards were badly injured and admitted to the A.O Clinic for treatment.
A spokesman for the Liaquat National Hospital said that Sattar's vital organs were functioning normally and he was in stable condition.
Sattar, 57, has assumed the charge of the MQM ever since the party members in Pakistan broke ties with founder and supremo Altaf Hussain after his anti-Pakistan speech on August 22 at a hunger strike camp in Karachi.
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Hussain, who is in exile in London since 1993, tweeted wished Sattar a speedy recovery.
Sattar had recently said that for the first time in over 30 years, MQM will not collect hides of sacrificial animals on Eidul Azha for its welfare projects, citing "unfavourable conditions" and "targeted" by state institutions.
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