In the rain-drenched southern Ticino region of Switzerland, two people died and four were injured when a mudslide slammed into a small residential building, regional police said.
On the other side of the border, a pensioner and his granddaughter were killed when another landslide engulfed a house on the Italian shores of Lake Maggiore, local media reported. Three other family members survived.
Those landslides were the latest of many to recently have hit northern Italy and southern Switzerland amid incessant rainfall over recent weeks.
In Switzerland, the bodies of two local women, aged 34 and 38, were pulled Sunday from the rubble of the three-story apartment building in Davesco-Soragno, near Lugano, after being hit by the mudslide shortly before 2:30 am (0130 GMT), Ticino police said.
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Four others, including a 44-year-old Italian man, had been injured and taken to hospital after the building, which reportedly housed eight people, collapsed.
Another resident had returned home after the landslide hit and was unharmed, but police said they were still searching the area to make sure no one else was under the rubble.
After weeks of heavy rain, southern Ticino has been hit by severe flooding, which worsened when Lake Lugano burst its banks in several places and Lake Maggiore threatened to do the same.
Just across Lake Maggiore, a 70-year-old man died Sunday after his house was partially buried in a "sea of mud" unleashed after the rain-doused hill behind the building gave way, Italian media reported.
Rescue workers managed to drag his 16-year-old granddaughter from the rubble after more than four hours of digging but she died later in hospital.