Today, in the twilight of his life, Mugabe resigned, loathed by millions of his citizens for a rule tarnished by despotism, cronyism, corruption and economic ruin.
Deserted by the forces that propped up his power for decades, Mugabe had faced the humiliation of impeachment proceedings launched by the ZANU-PF -- the party he had forged into a tool of unquestioning loyalty.
In a bombshell letter read to parliament by the speaker Jacob Mudenda, the 93-year-old said: "I Robert Gabriel Mugabe in terms of section 96 of the constitution of Zimbabwe hereby formally tender my resignation... with immediate effect."
As a child, Mugabe was a loner and studious, carrying a book to read even while tending cattle in the bush.
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His father, a carpenter, walked out on the family when he was 10, prompting the youngster to focus on his studies, qualifying as a schoolteacher at the age of 17.
In these formative years, Mugabe was an intellectual who initially embraced Marxism. He enrolled at Fort Hare University in South Africa, where he met many of southern Africa's future black nationalist leaders.
During his incarceration, he gained three degrees through correspondence, but the harsh years in prison also left a mark and honed his ruthlessness and guile.
His four-year-old son by his first wife, Ghanaian-born Sally Francesca Hayfron, died while he was behind bars. Rhodesian leader Ian Smith denied him leave to attend the funeral.
The conflict for independence that erupted in 1964, coupled with international sanctions, forced the Rhodesian government to the negotiating table. The country finally won independence as Zimbabwe in 1980.
In elections that year, Mugabe swept to power as prime minister, initially winning international plaudits for his policy of racial reconciliation and for extending improved education and health services to the black majority.
But the glory faded as Mugabe cracked down on dissent.
Nkomo, his former comrade-in-arms, was a first casualty. In 1982 he was dismissed from government, where he held the home affairs portfolio, after the discovery of an arms cache in his Matabeleland stronghold.
Mugabe's transformation into international pariah was made complete by his seizure of white-owned farms.
Aimed largely at placating angry war veterans who threatened to destabilise his rule, the land reform policy wrecked the crucial agricultural sector, caused foreign investors to flee and turned the bread basket of southern Africa into an economic basket case.
One of the world's most recognisable leaders with his thin stripe of moustache and thick-rimmed spectacles, Mugabe appeared immune to criticism.
At stage-managed events, he used blistering rhetoric to blame Western sanctions for his country's downward spiral, even though these measures were targeted at Mugabe personally and his henchmen rather than at Zimbabwe's economy.
For decades, the subject of who would succeed Mugabe was virtually taboo.
As he reached his 90s, he became visibly frail -- he had been rumoured for years to have prostate cancer, but according to the official account, his frequent trips to Singapore were for treatment related to his cataracts.
In the spotlight was Mugabe's ambitious second wife Grace, his former secretary who is 41 years his junior, and the father of his two sons and a daughter.
Quietly lampooned by critics as "Gucci Grace" for her shopping habits, she fought for the spoils with vice president Emmerson Mnangagwa, precipitating the army takeover.
Mugabe staged a last-ditch attempt to cling to office, making a TV address on Sunday that, to the astonishment of Zimbabweans, blithely ignored the clamour for him to quit.