Mumbai Indians are already through to the Play-offs while the hosts will try to consolidate their fourth position in the table and enhance their chances.
The hosts have replaced injured Ashish Nehra with Mohammed Siraj and Afghanistan's Mohammed Nabi has come in place of Kane Williamson.
Mumbai Indians have fielded an unchanged side.
Teams:
Sunrisers Hyderabad: David Warner (C), Shikhar Dhawan, Moises Henriques, Yuvraj Singh, Mohammad Nabi, Vijay Shankar, Naman Ojha, Bhuvneshwar Kumar, Rashid Khan, Siddarth Kaul and Mohammed Siraj.