West Indies' Lendl Simmons, playing his first match of the season, hammered the bowlers all around the park during his 66-run knock while his compatriot Kieron Pollard hit an unbeaten 63 to torment the hosts.
Daredevils lost its top-order quickly with young guns Sanju Samson (0), Shreyas Iyer (3) and Rishabh Pant (0) getting out cheaply.
Pant came into the match after an inspiring match-winning 97-run knock against Gujarat Lions.
They kept losing wickets and their innings folded for a mere 66 in 13.4 overs.
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Brief Scores:
Mumbai Indians: 212 for 3 in 20 overs. (L Simmons 6, K Pollard 63; C Anderson 1/29).
Delhi Daredevils: 66 all out in 13.4 overs.