Steep declines in TCS and Sun Pharma at 4.22 per cent and 4.80 per cent, respectively kept the index under pressure.
The 30-share Sensex has now lost over 602.34 points in the last three days after rising to 29,000-levels on Monday.
"Sentiments were downbeat from the beginning in response to disappointing earnings of TCS, and negativity further accelerated as the day progressed. It was reflected across the board as majority of sectoral indices ended in red," said Jayant Manglik, President-retail distribution of Religare Securities.
It finally settled down by 223.94 points or 0.78 per cent at 28,442.10. The gauge had closed at 28,260.14 on April 1.
Also Read
On weekly basis, the Sensex tumbled by 437.28 points or 1.51 per cent and has broke its three-week winning run.
The 50-share NSE Nifty also dropped by 100.70 points or 1.16 per cent to close the day at 8,606.00 after shuttling between 8,699.85 and 8,596.70 intraday.
The biggest losers on the Sensex included, Wipro, Infosys, Sun Pharma, Axis Bank, Bharti Airtel, GAIL, Bajaj Auto, Hero MotoCorp and HDFC Bank.
However, shares of Reliance Industries after rising to Rs 943.80 during the session on expectations of encouraging earnings, reacted to profit-bookings at the fag-end and closed a shade lower at Rs 926.85.
Tata Steel, Sesa Sterlite, Hindalco, BHEL, NTPC, Tata Power and Hindustan Unilever also rose on the day.
Globally, Asian markets ended in negative zone, while European markets were higher in their early trade.