Cheerful information posters festoon roadsides ahead of the 12-day survey, which will see tens of thousands of census takers - mainly teachers - fan out from the mountainous north to conflict-scarred jungle borderlands and the tropical south.
With even basic information like population based on estimates, the survey - which begins on Sunday - aims to visit every household to plug information gaps that hamper policymakers.
Local people, repressed under decades of secretive military rule that ended in 2011, have expressed suspicion of the collection of household information including questions on movement and economic activity.
"Despite reforms and amnesties, peaceful protesters and political activists are still subject to arbitrary detention and other human rights abuses by state security forces," said Daniel Gray of risk analysts Maplecroft.
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"Equipping Myanmar's largely authoritarian government with up-to-date information on its citizens is therefore a cause for concern."
Its Myanmar chief Janet Jackson has sought to reassure people that it will be impossible to trace data back to individuals.
"The deep mistrust cannot be washed away in one swoop. It's going to take time," she told AFP.
She said it was imperative to get "credible" new data to replace unreliable information from the last census in 1983 to help set priorities for everything from national education and health provision, to town planning.
Buddhist nationalists in western Rakhine State have campaigned for a boycott of the census over fears local Muslims could use it to boost calls for political rights.