More than 330,000 people have been affected by torrential monsoon rains that triggered flash floods and landslides, cutting off communications as the deluge engulfed roads and destroyed bridges.
Residents have raced to bolster sand-bag defences along the Irrawaddy river in the southwest as floodwaters swell the mighty waterway, swamping dozens of villages as the waters drain from further north.
"Nothing like this has happened before, but I am not the only one suffering," said Soe Min Paing, a fisherman from Kyauk Taing village in Nyaung Don township, whose home has been inundated.
Impoverished western Rakhine state has suffered the highest number of fatalities so far, the state-run Global New Light of Myanmar reported, with at least 55 killed after Cyclone Komen tore across the Bay of Bengal last week.
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The heavy monsoon downpours have caused devastation across large parts of South and Southeast Asia in recent weeks, claiming hundreds of lives and displacing millions.
Myanmar's previous junta government was accused of indifference in its sluggish response to Cyclone Nargis in May 2008, a crisis which left nearly 140,000 people dead or missing.
The quasi-civilian regime which replaced outright military rule in 2011 has been eager to show it is mobilising.
But many of those affected by the flooding appear not to be relying on government help, either trying to cope alone or turning to local monasteries or community groups.
More than 200,000 acres of farmland have been ruined and large numbers of animals killed as well as the thousands of homes lost, according to state media.