The remote area -- which covers Shan State, Laos and northern Thailand -- churns out huge quantities of opium and meth that are smuggled across porous borders to countries around Asia.
Myanmar soldiers and border officers arrested a man with 250 kilograms of crystal meth in the back of his car early yesterday at a toll gate in eastern Shan state.
Highly pure crystal methamphetamine -- known as "ice" -- is extremely addictive and fetches hefty sums.
"The arrested man and drugs were systematically transferred to anti-drugs squad," the statement said.
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Authorities in Myanmar, Laos and Thailand have struggled to dismantle the sprawling drug networks that funnel Myanmar- made narcotics through the region.
Some of the drugs head as far afield as Australia -- the world's largest per capita consumer of crystal meth -- where the price surges.
While low-level mules are routinely arrested, it is rare for Southeast Asian authorities to net players higher up the food chain.