All life on Earth came from one common ancestor - a single-celled organism - but what it looked like, how it lived and how it evolved into today's modern cells is a four billion year old mystery being solved by researchers at University College London (UCL) using mathematical modelling.
The findings suggest for the first time that life's Last Universal Common Ancestor (LUCA) had a 'leaky' membrane.
The research helps scientists answer two of biology's biggest questions: Why all cells use the same bizarre, complex mechanism to harvest energy and why two types of single-celled organism that form the deepest branch on the tree of life - bacteria and archaea - have completely different cell membranes.
The team modelled how the membrane changed, enabling LUCA's descendants to move to new, more challenging environments and evolve into two distinct types of single-celled organism, bacteria and archaea, creating the deepest branch of the tree of life.
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Bacteria and archaea share many common features such as genes, proteins and mechanisms of reading DNA, initially leading scientists to believe they were just different types of bacteria.
Their classification changed in the 1970's after extreme differences were found in the way they replicate DNA and in the structure of their cell membrane. As they both stemmed from LUCA, scientists set out to find answers in the structure and function of LUCA's membrane.
Data from the study strongly suggest that LUCA lived in the area where ancient seawater, dense with positively charged particles called protons, mixed with warm alkaline vent fluid, which contained few protons.
The study was published in the journal PLOS Biology.