Tomic has been in good form leading into the year's opening Grand Slam, making the final of the Sydney International, and poses an unwanted early headache for the world number one.
Nadal, who opened his season by winning the Qatar Open final against Gael Monfils, knows he will have his hands full with Tomic, 21, backed by a traditionally vocal crowd.
Nadal's only career meeting against Tomic was in the Melbourne third round in 2011, when the young Australian showed class and potential before going out 6-2, 7-5, 6-3.
"It's a tough start. But what I thought is just I need to be ready and just practise with great tactics every day, try to do the right things in every moment to arrive in the first round competitive. That's the only way."
Despite the early roadblock Nadal, who missed Melbourne last year because of his troublesome injured knees, is feeling fit and confident he can prevail against the youngster, having come through a physical test against Monfils in Doha.