Cassini is on course to dive into Saturn to ensure that the planet's moons - in particular Enceladus, with its subsurface ocean and signs of hydrothermal activity - remain pristine for future exploration.
The spacecraft's fateful dive on September 15 is the final beat in the mission's Grand Finale, 22 weekly dives, which began in late April, through the gap between Saturn and its rings.
The mission's final calculations predict loss of contact with the Cassini spacecraft will take place a minute after it reaches an altitude of about 1,915 kilometres above the planet's estimated cloud tops.
During its dive into the atmosphere, the spacecraft's speed will be about 113,000 kilometres per hour.
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The final plunge will take place on the day side of Saturn, near local noon, with the spacecraft entering the atmosphere around 10 degrees north latitude.
When Cassini first begins to encounter Saturn's atmosphere, the spacecraft's attitude control thrusters will begin firing in short bursts to work against the thin gas and keep Cassini's saucer-shaped high-gain antenna pointed at Earth to relay the mission's precious final data.
Once they are firing at full capacity, the thrusters can do no more to keep Cassini stably pointed, and the spacecraft will begin to tumble.
When the antenna points just a few fractions of a degree away from the Earth, communications will be severed permanently.
The predicted altitude for loss of signal is about 1,500 kilometres above Saturn's cloud tops. From that point, the spacecraft will begin to burn up like a meteor.
Due to the travel time for radio signals from Saturn, which changes as both Earth and the ringed planet travel around the Sun, events currently take place there 83 minutes before they are observed on Earth.
"The spacecraft's final signal will be like an echo. It will radiate across the solar system for nearly an hour and a half after Cassini itself has gone," said Earl Maize, Cassini project manager at NASA's Jet Propulsion Laboratory (JPL) in the US.
Cassini's last transmissions will be received by antennas at NASA's Deep Space Network complex in Australia.
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