"Based on observed navigation data, congratulations. MAVEN is now in orbit," said Dave Folta of NASA's Goddard Space Flight Center.
The unmanned orbiter has traveled more than 10 months and 711 million kilometers to reach Mars yesterday for a first-of-its kind study of the planet's upper atmosphere.
The data from the Mars Atmosphere and Volatile Evolution (MAVEN) spacecraft aims to help scientists understand what happened to the water on Mars and the carbon dioxide in its atmosphere several billion years ago.
MAVEN's findings are also expected to help add to knowledge of how humans could survive on a future visit to the Red Planet, perhaps as early as 2030.
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"Mars is a cool place, but there is not much atmosphere," said John Clarke, of the MAVEN science team.
"It is very cold, it is well below zero. The atmosphere is about half a percent of what we are breathing," he added.
Next, MAVEN will enter a six-week phase for tests.
Then, it begins a one-year mission of studying the gases in Mars's upper atmosphere and how it interacts with the sun and solar wind.
Much of MAVEN's year-long mission will be spent circling the planet 3,730 miles above the surface.
However, it will execute five deep dips to a distance of just 78 miles above the Martian landscape to get readings of the atmosphere at various levels.
The US space agency's latest robotic vehicle, Curiosity, is exploring Gale Crater and Mount Sharp, looking for interesting rocks and returning data on whether the Martian environment shows evidence of a past ability to support life.
Later this week, an Indian spacecraft, the Mars Orbiter Mission, will be on course to reach Mars.
The unmanned MOM probe is set to enter Mars's orbit in the next few years after 10 months in space, marking India's first mission to the planet to search for evidence of life.