The ultimate goal of the crash is to help make helicopters and other vertical take-off and landing vehicles more serviceable - able to carry more passengers and cargo - quicker, quieter, safer and greener, NASA said.
Improved designs might allow helicopters to be used more extensively in the airspace system.
"We have instrumented a former Marine helicopter airframe with cameras and accelerometers," said lead test engineer Martin Annett.
"Almost 40 cameras inside and outside the helicopter will record how 13 crash test dummies react before, during and after impact," said Annet.
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Just before impact, pyrotechnic devices release the suspension cables from the helicopter to allow free flight.
For the first time ever in any test, technicians installed a video game motion sensor in the helicopter. The helicopter will hit the ground at about 48.2kph.
"We want to see if it is useful as an additional way to track the movements of the dummies," said test engineer Justin Littell.
The outside of the fuselage also is new for this test. Technicians painted one entire side in black polka dots over a white background - a photographic technique called full field photogrammetry.
Another crash test of a similar helicopter equipped with additional technology, including composite airframe retrofits, is planned for next year.
NASA will use the results of both tests in efforts to improve rotorcraft performance and efficiency, in part by assessing the reliability of high performance, lightweight composite materials.
Researchers also want to increase industry knowledge and create more complete computer models that can be used to design better helicopters.