The launch of a NASA ocean winds sensor to the ISS this month inaugurates a new era of Earth observation, NASA said.
Before the end of the decade, six NASA Earth science instruments will be mounted to the station to help scientists study our changing planet.
The first NASA Earth-observing instrument to be mounted on the exterior of the space station will launch from Cape Canaveral Air Force Station, earlier than September 19.
The second instrument is the Cloud-Aerosol Transport System (CATS), a laser instrument that will measure clouds and the location and distribution of airborne particles such as pollution, mineral dust, smoke, and other particulates in the atmosphere.
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CATS will follow ISS-RapidScat on the fifth SpaceX space station resupply flight, planned for December.
"We're seeing the space station come into its own as an Earth-observing platform," said Julie Robinson, chief scientist for the International Space Station Programme at NASA's Johnson Space Centre in Houston.
The space station-based instruments join a fleet of 17 NASA Earth-observing missions currently providing data on the dynamic and complex Earth system.
ISS-RapidScat and CATS follow the February launch of the Global Precipitation Measurement Core Observatory, a joint mission with the Japan Aerospace Exploration Agency.
Most of the agency's free-flying, Earth-observing satellites orbit the planet over the poles at altitudes higher than 400 miles in order to gather data from all parts of the planet.
"With the space station we don't have to build a spacecraft to gather new data - it's already there," said Stephen Volz, associate director of flight programmes in the Earth Science Division at NASA Headquarters in Washington.
Two additional NASA Earth science instruments are scheduled to launch to the station in 2016.