The findings from the 13-year study confirm that Neanderthal burials took place in western Europe prior to the arrival of modern humans.
"This discovery not only confirms the existence of Neanderthal burials in Western Europe, but also reveals a relatively sophisticated cognitive capacity to produce them," said William Rendu, the study's lead author and a researcher at the Center for International Research in the Humanities and Social Sciences (CIRHUS) in New York City.
The findings center on Neanderthal remains first discovered in 1908 at La Chapelle-aux-Saints in southwestern France.
However, their conclusions have sparked controversy in the scientific community ever since, with skeptics maintaining that the discovery had been misinterpreted and that the burial may not have been intentional.
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Beginning in 1999, Rendu and his collaborators, including researchers from the University of Bordeaux and Archeosphere, a private research firm, began excavating seven other caves in the area.
In this excavation, which concluded in 2012, the scientists found more Neanderthal remains - two children and one adult - along with bones of bison and reindeer.
As part of their analysis, the study's authors also re-examined the human remains found in 1908.
In contrast to the reindeer and bison remains at the site, the Neanderthal remains contained few cracks, no weathering-related smoothing, and no signs of disturbance by animals.
"The relatively pristine nature of these 50,000-year-old remains implies that they were covered soon after death, strongly supporting our conclusion that Neanderthals in this part of Europe took steps to bury their dead," said Rendu.
The study appears in the journal Proceedings of the National Academy of Sciences.