Soon after assuming charge last evening, Raju said her ascendance to the top post had boosted the morale of other women IPS officers in the state.
The DGP said she wants to make police stations more women-friendly and providing security is her top priority.
Thanking the government for reposing faith in her, Raju said there were challenges ahead in Karnataka where assembly elections are due early next year.
She also said 'Tipu Jayanthi', being opposed by the BJP, is a "big challenge" but she was confident of handling the situation.
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An IPS officer of 1983 batch, 57-year-oldRaju replaced Rupak Kumar Dutta who retired.
Though there were other claimants for the post, the government gave preference to the seniority.
Her husband D N Narasimha Raju had retired as principal secretary to the chief minister last year.