The shocking loss with white pieces means that Negi will have to now battle it out in the tie-break games of shorter duration as the final score after the two-game mini-match stands tied at 1-1.
National champion G Akash made his expected exit from the 128-player event with a memorable game wherein he held world number three Caruana to a creditable draw with black pieces.
Having lost the first game of the match, the draw only helped Akash to gain some rating but this is one result he will cherish for a long time.
To decide the winner now, two games under rapid chess rules will be played with 25 minutes to both players and a ten second addition after every move.
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If still tied, two games of 10 minutes will be followed by two games of five minutes each and if the deadlock persists, an Armageddon game will decide the winner in the USD 1.6 million knockout event.
Kryvoruchko had to part with a pawn also and it was smooth sailing for the Indian till disaster struck on move 42. Negi followed a mistake with a blunder and the fate of the game was soon sealed.