The 'How I Met Your Mother' star took to micro-blogging site Twitter and shared a picture of the happy couple exchanging vows.
"Guess what? David Burtka and I got married over the weekend. In Italy. Yup, we put the 'n' and 'd' in 'husband'," Patrick Harris captioned the picture.
The 41-year-old actor came out as gay in 2006 and got engaged to actor and chef Burtka, 39, in September 2007.
The couple has been dating since 2004. They are fathers to twins Gideon and Harper, who were born via a surrogate mother in 2010.