It was unclear if Netanyahu was suggesting no settlements would be dismantled in any peace deal with the Palestinians, which would mark a significant change and raise further doubts over future possibilities of a two-state solution.
A spokesman for Netanyahu did not respond to a request for further explanation.
Netanyahu was speaking in parliament at a special session marking 50 years since the 1967 Six-Day War, when Israel's occupation of the West Bank began, to an audience of lawmakers and invited settler leaders.
Netanyahu has said he still supports a two-state solution, but peace advocates allege his actions show otherwise.
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Proposals for future peace deals with the Palestinians typically involve land swaps, with far-flung settlements evacuated and larger settlement blocs remaining under Israeli control.
His comments came as Netanyahu faced heavy criticism from settler leaders who accuse him of failing to advance settlement projects.
The settlers, pillars of support for Netanyahu's right- wing government, are still smarting over the February demolition of the Amona rogue settlement outpost in the West Bank.
He spoke today of a plan to rehouse Amona evacuees at a new site in the West Bank, which Israeli settlement watchdog Peace Now says would be the first new government-approved settlement in about 25 years.
Construction in recent years has involved expanding existing settlements in the West Bank, with many countries warning it is gradually eating away at any chance of a two- state solution with the Palestinians.