Benjamin Netanyahu, who speaks at the General Assembly Thursday, also said he planned to review the situation in neighbouring Syria as well as the nuclear accord between major powers and Iran, which Israel strongly opposes.
"Israel desires peace with the Palestinians, who continue to spread lies about our policy on the Temple Mount," Netanyahu said in a statement, using the Jewish name for the Al-Aqsa mosque compound in Jerusalem.
The sensitive compound has been hit by a series of clashes between Israeli security forces and Palestinian protesters in recent weeks, prompting international calls for calm at the site in Israeli-annexed east Jerusalem.
The clashes have coincided with a series of Jewish religious holidays, which often see an increase in the number of Jews visiting.
Israeli authorities say they have carried out raids at the compound to stop rioters from disrupting visits by non-Muslims.
Police have fired tear gas and stun grenades at protesters throwing stones and petrol bombs while barricading themselves inside the mosque itself.
Netanyahu has said repeatedly he is committed to maintaining the status quo despite the views of some hardliners within his governing coalition.
A campaign by a hardline Jewish minority to build a new temple at the site has further stoked suspicions among Palestinians.
"Israel is committed to respecting the status quo, and the fact that Palestinians are bringing weapons into the site desecrates the holy place and violates the status quo," Netanyahu said today.
He has said the lifting of sanctions under the deal will allow Iran to further back proxy militants in the region, including Israeli enemies Hezbollah and Hamas.
Netanyahu lobbied fiercely against the deal before it was adopted and sharply criticised it in the weeks afterward, but has recently eased off amid criticism at home about damage to Israel's relations with the United States, its most important ally.
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