"Lab results confirm a new case of Ebola virus disease in Liberia -- a 30-year-old woman who died yesterday afternoon while being transferred to a hospital in the capital Monrovia," the World Health Organization (WHO) said in a statement.
A Liberian health ministry official confirmed the case to AFP and said further details would be released later on the woman's death, with an emergency meeting convened to co-ordinate a response.
A resurgence of Ebola in a rural Guinean community has killed seven people in the last few weeks, but it is not known if the new Liberian case is linked.
They were to "begin case investigation and identification of individuals who may have been in contact," the statement said.
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Liberia was the country worst hit by a two-year outbreak that saw 4,800 deaths. It discharged its last two Ebola patients from hospital in December, after which the country was monitored for 42 days before being given the all-clear.
The WHO had said on Tuesday that the Ebola outbreak in West Africa no longer constituted an international emergency, voicing confidence that remaining isolated cases in the affected countries can be contained.
Ebola causes severe fever and muscle pain, weakness, vomiting and diarrhoea. In many cases it shuts down organs and causes unstoppable internal bleeding. Patients often succumb within days.
The virus is spread through close contact with the sweat, vomit, blood or other bodily fluids of an infected person, or the recently deceased.