A study involving the recently approved CD19-targeting chimeric antigen receptor (CAR) T cell therapy shows that 42 per cent of patients with aggressive large B-cell lymphoma remained in remission at 15 months following treatment with axi-cel.
The study also reported measurable responses in 82 per cent of patients and complete responses in 54 per cent, researchers said.
Fifty-six per cent were alive at 15 months following therapy, with some remaining cancer free two years post- treatment, they said.
"This study demonstrated that axi-cel provides remarkable improvement in outcomes over existing therapies for these patients who have no curative options," said Neelapu, who led the study published in The New England Journal of Medicine.
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The study, which began in April 2015, administered axi- cel to 108 patients who had failed prior chemotherapy and autologous stem cell transplantation.
The patients' T-cells were extracted through a process called leukapheresis and genetically reengineered with CAR molecules that help T-cells attack cancer cells. The reengineered T cells are infused back into the patient.
"This is the first FDA-approved gene therapy to treat adult lymphoma. Axi-cel consists of the patients' own T cells that have been reprogrammed, and then reinfused to detect and destroy lymphoma," said Frederick Locke from Moffitt Cancer Center in the US.
"Many patients' lymphoma tumours melted away within a month. The long term follow-up results of the ZUMA-1 trial show that axi-cel remissions can last years, and these are patients that did not respond to chemotherapy," said Locke.
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