The microneedle drug monitoring system developed by researchers at the University of British Columbia (UBC) in Canada and the Paul Scherrer Institut (PSI) in Switzerland could replace costly, invasive blood draws and improve patient comfort.
The new system consists of a small, thin patch that is pressed against a patient's arm during medical treatment and measures drugs in their bloodstream painlessly without drawing any blood.
The tiny needle-like projection, less than half a millimetre long, resembles a hollow cone and doesn't pierce the skin like a standard hypodermic needle.
Microneedles are designed to puncture the outer layer of skin, which acts as a protective shield, but not the next layers of epidermis and the dermis, which house nerves, blood vessels and active immune cells.
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The microneedle was developed to monitor the antibiotic vancomycin, which is used to treat serious infections and is administered through an intravenous line.
Patients taking the antibiotic undergo three to four blood draws per day and need to be closely monitored because vancomycin can cause life-threatening toxic side effects.
The microneedle collects just a tiny bit of this fluid, less than a millionth of a millilitre, and a reaction occurs on the inside of the microneedle that researchers can detect using an optical sensor.
This technique allows researchers to quickly and easily determine the concentration of vancomycin.
"This is probably one of the smallest probe volumes ever recorded for a medically relevant analysis," said Urs Hafeli, associate professor at UBC.
"The combination of knowhow from UBC and PSI, bringing together microneedles, microfluidics, optics and biotechnology, allowed us to create such a device capable of both collecting the fluid and performing the analysis in one device," said Victor Cadarso, a research scientist at PSI.