The minister said Russia has prepared for three possible scenarios in the event of tougher economic sanctions.
The less severe one presumes sanctions on "luxury products, caviar, furs, etc," while the worst "includes the whole complex: metals, fertilisers, oil, gas, and so forth, taking into account prices and volumes."
In this case, "economic growth rates go seriously into the negative," he was quoted as telling the Rossiya channel, though he added that the economy can still "support" this outcome.
Ulyukayev's comments come on the heels of Ukraine's signing of the Association Agreement with the European Union yesterday, and a decision by President Petro Poroshenko to extend a shaky truce with separatist fighters in eastern Ukraine by three days.
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The signing of the agreement -- a 1,200-page document defining the political and trade terms under which Kiev will slip from the Kremlin's embrace -- drew threats of retaliation from Moscow.
Western leaders have warned President Vladimir Putin of tougher sanctions on entire sectors of the Russian economy if his policy on Ukraine, notably the alleged material support of the pro-Russian rebels, does not change.
Last week Russia's central bank said the country's growth rate would slow to just 0.4 per cent this year.
EU leaders yesterday gave Moscow three more days to clearly back the Kiev government's peace plan or face the new sanctions.
Moody's yesterday cut Russia's credit rating to "negative" citing a "geo-political event risk" for Moscow, including from tougher sanctions, and said that it would further downgrade "if the domestic growth outlook were to deteriorate further.