The cells have better preservation stability and the technology is generalisable to other types of stem cells.
Stem cell therapies work by promoting endogenous repair; that is, they aid damaged tissue in repairing itself by secreting "paracrine factors," including proteins and genetic materials.
While stem cell therapies can be effective, they are also associated with some risks of both tumor growth and immune rejection.
Also, the cells themselves are very fragile, requiring careful storage and a multi-step process of typing and characterisation before they can be used.
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The researchers then harvested growth factor proteins from cultured human cardiac stem cells and added them to the PLGA. Finally, they coated the particle with cardiac stem cell membrane.
"We took the cargo and the shell of the stem cell and packaged it into a biodegradable particle," said Ke Cheng, associate professor at NC State University.
When tested in vitro, both the CMMP and cardiac stem cell promoted the growth of cardiac muscle cells.
Due to its structure, CMMP cannot replicate - reducing the risk of tumor formation.
"The synthetic cells operate much the same way a deactivated vaccine works," Cheng said.
"Their membranes allow them to bypass the immune response, bind to cardiac tissue, release the growth factors and generate repair, but they cannot amplify by themselves. So you get the benefits of stem cell therapy without risks," he said.
The manufacturing process can be used with any type of stem cell, researchers said.
"We are hoping that this may be a first step toward a truly off-the-shelf stem cell product that would enable people to receive beneficial stem cell therapies when they're needed, without costly delays," Cheng said.