Steffan de Mistura, a Swedish-Italian diplomat, is stepping into a mission that has frustrated two previous high-profile predecessors: Finding a resolution to a conflict that has killed more than 190,000 people and has driven a third of Syria's population some 9 million people from their homes.
De Mistura and his Egyptian deputy, Ramzy Ezzedine Ramzy, who were named to their posts in July, crossed by land from neighboring Lebanon and upon arrival in Damascus met with Deputy Foreign Minister Faisal Mekdad. It was not immediately clear if de Mistura will meet President Bashar Assad during his visit.
The conflict has taken a new turn with the rising power this year of the Islamic State militant group, which holds large parts of the north and east and has also taken over large parts of neighboring Iraq, imposing strict rule and sparking a flight of minority groups.
A government warplane shelled the nearby town of Douma, killing at least nine people, according to a rebel who uses the name Abu Yazan, and the Britain-based Syrian Observatory for Human Rights. The exchange was the deadliest in the capital since August 3, when 11 people were killed in Damascus.
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