At least five early morning raids hit targets linked to Al-Qaeda in the Arabian Peninsula (AQAP) in the southern Shabwa and central Baida provinces, security sources told AFP.
There were no immediate reports of casualties.
Among the areas from which the radical group pulled its operatives is the Baida town of Ghail, where top AQAP commander Abdulelah al-Dhahab has reportedly been holed up, the sources said.
Suspected AQAP gunmen meanwhile killed five soldiers at a checkpoint in the southern province of Abyan, which has itself been hit by air strikes in recent days, security sources and medics there said.
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The Pentagon on Friday confirmed it had carried out more than 30 strikes against AQAP, conducted in partnership with the Yemeni government.
Local officials and tribal sources told AFP that at least 20 jihadists were killed on Thursday and Friday.
The bombing campaign comes after a botched January 29 raid against AQAP left multiple civilians and a US Navy SEAL dead in the first military strike ordered by President Donald Trump.
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