The front-runner for the Democratic presidential nomination said that a leader with a strong vision for the future and skill and determination can fight these threats.
"We need a leader who has a strong vision for the future, and the skill and determination to get us there. We can't stop the world from changing, but we can help to shape those changes, and we can do that by beating with strength, smarts and unyielding commitment to our values," she said in her address to the Brooking Institute.
"The next President will face threats from many quarters, from those we see today like terrorism from ISIS, aggressiveness from Putin, pandemics like Ebola, to all those we can't predict yet," Clinton said.
"I saw that when I was first lady, senator, secretary of state, that when America leads with principal and purpose, other people and governments are eager to join us," she said, adding that no country comes close to matching our advantages, the strength of US economy, the skill of its work force, tradition of innovation, unmatched network of alliances and partnership.