The Commission took suo moto cognizance of media reports on the incident.
In a statement, quoting media reports, NHRC said that as many as 25 passengers died and 50 were injured when two trains - Kamayani Express and Janta Express - derailed within a difference of a few minutes.
The incident was caused by alleged "lapses" on part of the railway authorities, the statement also stated.
For the first time, two trains derailed at the same spot in quick succession at a place where the track location was not marked as vulnerable in Bhopal Division's Disaster Plan.