Expressing its concern over the incident, the Commission said in a statement today that a "high-level probe into the matter is immediately required to ascertain the negligence and errors, if any, behind the incident, which involves the right to life".
At least 26 persons died after a massive explosion in one the boilers at the state-run power giant's Unchahar plant yesterday.
The rights panel said there was need to ensure that such tragedies do not recur.
"The state government has been directed to look into the matter and take utmost care to see that the families of the deceased are suitably compensated by way of monetary relief, without any delay," NHRC said.
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The administration has been asked to ensure that the "best treatment" is provided to those injured in the incident, and steps are taken for their rehabilitation, it added.
The state-run power major said that around 80 people were rushed to the NTPC Hospital, most of whom were discharged after first-aid.
Prime Minister Narendra Modi has approved ex-gratia payment of Rs 2 lakh each for the families of those killed and said he was "deeply pained" by the accident at the power plant.
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