After a weak start, the market staged a recovery in second half of trading after Republican Donald Trump was declared the 45th President of the US.
Short covering in healthcare and PSU banks helped the market cut some losses.
Overseas, most European markets were trading lower, while Asian stocks fell across the board.
The 50-share Nifty opened lower at 8,067.50, and drifted further to 8,002.25 before ending at 8,432, a loss of 111.55 points, or 1.31 per cent, from its last close.
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On the sectoral front, realty fell by 11.60 per cent, followed by IT (3.25 per cent), auto (2.58 per cent), metal (1.41 percent), FMCG (2.23 percent) and infra (1.21 per cent).
However, PSU Bank surged by 2.10 per cent and Pharma by 1.92 per cent.
Index laggards were Ambuja Cements (5.66 per cent), Maruti (4.87 per cent), TCS (4.96 per cent), Tech Mahindra (4.33 per cent), UltraTech Cement (4.88 per cent), Hero MotoCorp (3.94 per cent), BHEL (3.35 per cent) and Tata Power (3.29 per cent).
The gainers list included Dr Reddy's (5.24 per cent), Sun Pharma (3.99 per cent), SBI (2.91 per cent), PowerGrid (1.81 per cent) and GAIL (1.69 per cent).
Turnover in the cash segment climbed to Rs 34,064.90 crore, from Rs 19,450.50 crore as on Tuesday.
A total of 16,960.67 lakh shares changed hands in 1,13,95,682 trades.
The market capitalisation of NSE stood at Rs 107,32,043.27 crore.
Disclaimer: No Business Standard Journalist was involved in creation of this content