Selling was seen mainly in metal, infra, IT, media, PSU Bank, realty, auto, pharma and energy counters amid weakness in European stocks.
European markets were posting sharp losses, dragged down by mining and healthcare stocks as investors were cautious ahead of a speech by Federal Reserve Chair Janet Yellen that could provide hints on the timing of a US interest rate hike.
In Asia, Nikkei index and China's Shanghai Composite ended marginally lower, while Hong Kong's Hang Seng edged higher.
It witnessed an intra-day movement of about 99.40 points.
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On the sectoral front, Metal fell by 1.61 per cent, followed by PSU Bank (1.26 per cent), Infra (1.14 per cent), IT (1.12 per cent), Media (1.11 per cent), Realty (0.71 per cent), Auto (0.61 per cent), Pharma (0.40 per cent), Energy (0.35 per cent) and Banks (0.27 per cent).
However, Nifty FMCG gained 0.40 per cent.
Notable Index laggards were Adani Ports (3.09 per cent), Wipro (3.01 per cent), Idea (2.75 per cent) , Zee (2.11 per cent), Bharti Infratel (2.11 per cent), TechM (2.10 per cent), HDFC (1.99 per cent), Infosys (1.94 per cent), SBI (1.93 per cent) and Tata Steel (1.83 per cent).
A total of 942 scrips declined, 640 rose, while 75 were unchanged. Total securities that hit their price band were 96.
Turnover in cash segment rose to Rs 25,162.87 crore from Rs 18,386.37 crore as on Wednesday.
A total of 12,782.31 lakh shares changed hands in 82,08,859 trades. The market capitalisation of NSE stood at Rs 107,15,110.44 crore.
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